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| Title |
Applied Spectroscopy
|
| Semester |
E2024
|
| Master programme in |
Chemical Biology
|
| Type of activity |
Course |
| Teaching language |
English
|
| Study regulation | |
| REGISTRATION AND STUDY ADMINISTRATIVE | |
| Registration |
Sign up for study activities at stads selvbetjeningwithin the announced registration period, as you can see on the Studyadministration homepage. When signing up for study activities, please be aware of potential conflicts between study activities or exam dates. The planning of activities at Roskilde University is based on the recommended study programs which do not overlap. However, if you choose optional courses and/or study plans that goes beyond the recommended study programs, an overlap of lectures or exam dates may occur depending on which courses you choose. |
| Number of participants |
|
| ECTS |
5
|
| Responsible for the activity | |
| Head of study |
Frederik Diness (diness@ruc.dk)
|
| Teachers |
|
| Study administration |
INM Registration & Exams (inm-exams@ruc.dk)
|
| Exam code(s) |
U60043
|
| ACADEMIC CONTENT | |
| Overall objective |
Spectroscopic methods play an important role in the analysis and identification of molecules and their structures. Nuclear Magnetic Resonance (NMR), Infra-red spectroscopy (IR) and mass spectrometry (MS) are used to characterize a diverse range of molecules, many of which are derived from a wide variety of sources or used in numerous applications. Some examples include molecules isolated from Nature (plants, animals and other biological sources) that possess important biological activity, or molecules involved in the discovery and development of medicines, such as the products of organic chemistry reactions. The central theme of the course is the application of spectroscopic techniques for the structural analysis and identification of organic and bioorganic molecules including macromolecules. During lectures, the students will be acquainted with the theory behind each method, including one- and two-dimensional proton and carbon Nuclear Magnetic Resonance (NMR) spectroscopy and electron and electrospray ionization mass spectrometry (EI- and ESI-MS). Throughout the course, problem solving exercises and worked examples discussed in class will demonstrate and illustrate approaches employed for the analysis and interpretation of different types of spectral data, which are used to reveal detailed structural information, and ultimately facilitate the identification or characterization of known and unknown molecules of varying degrees of complexity. Applied Spectroscopy students will therefore analyze and discuss spectra recorded for a number of organic molecules, with an emphasis on the interpretation of the data. This will enhance an understanding of the theory and concepts described, and reveal the power of the spectroscopic methods when used in combination. |
| Detailed description of content |
Aspects of the following topics will be discussed throughout the course, or represent relevant background reading* to the course: Infra-red spectroscopy (Ch. 2)* Mass spectrometry: (Chs. 3 and 4) Basic NMR Concepts (Ch. 5)* Carbon-13 Spectra and other Nuclei (Ch. 6) Spin-Spin Coupling (Ch. 7) Advanced Techniques in 1D NMR (Ch. 8 / Ch. 6) Advanced Techniques in 2D NMR (Ch. 9 / Ch. 7) ** Chapters in Simpson text. Detailed Teaching Objectives and Learning Outcomes After successful completion of the course the student will be able to demonstrate and apply: Knowledge of
Skills in
Learning outcomes:
|
| Course material and Reading list |
Textbooks: D. L. Pavia, G. M. Lampman, et al., Introduction to Spectroscopy, 5th Ed., Cengage Learning, 2015. J. H. Simpson, Organic Structure Determination Using 2-D NMR Spectroscopy: A Problem-Based Approach, 2nd Ed., Academic Press, 2012. Chapters 6 and 7, together with part of the problem chapters 11-16. https://doi.org/10.1016/C2010-0-65520-9 (use RUC login) Selected text: H. Friebolin, Basic One- and Two-Dimensional NMR Spectroscopy, VCH, 1991. Selected sections of chapters 8-10. Other materials: Powerpoint slides and problems will be posted on Moodle during the course. |
| Overall plan and expected work effort |
5 ECTS corresponds to 135 hours of work The work load for the student: Contact time:
Study and preparation time:
Total 135 hours |
| Format |
|
| Evaluation and feedback |
The course includes formative evaluation based on dialogue between the students and the teacher(s). Students are expected to provide constructive critique, feedback and viewpoints during the course if it is needed for the course to have better quality. Every other year at the end of the course, there will also be an evaluation through a questionnaire in SurveyXact. The Study Board will handle all evaluations along with any comments from the course responsible teacher. Furthermore, students can, in accordance with RUCs ‘feel free to state your views’ strategy through their representatives at the study board, send evaluations, comments or insights form the course to the study board during or after the course. |
| Programme |
The course is organized around a combination of lectures (powerpoint, boardwork, and discussion), problem solving workshops and instrument training and operation. See study.ruc.dk for a detailed course calendar, and the course page on Moodle for a schedule, course description and other documents, together with lecture notes and problem solving questions. Each lecture section is followed by a problem-solving workshop, organized according to the course schedule on Moodle. Questions associated with a particular lecture section are found at the end of each set of lecture notes or are selected from a past exams document. Students are expected to complete or attempt the problem solving questions associated with a particular workshop, before it takes place, and be prepared to present their solutions, in whole or in part, during the workshop. |
| ASSESSMENT | |
| Overall learning outcomes |
After successful completion of the course the student will be able to:
|
| Form of examination |
Individual written portfolio and oral exam The character limit of the portfolio is 2,400-24,000 characters, including spaces. Examples of written products are exercise responses, talking points for presentations, written feedback, reflections, written assignments. The preparation of the products may be subject to time limits. The character limits include the cover, table of contents, bibliography, figures and other illustrations, but exclude appendices. Time allowed for the exam including time used for assessment: 20 minutes. The assessment is an overall assessment of the written product(s) and the subsequent oral examination. Permitted support and preparation materials for the oral exam: Personal notes, own reports and assignments. Assessment: 7-point grading scale Moderation: Internal co-assessor |
| Form of Re-examination |
Samme som ordinær eksamen / same form as ordinary exam
|
| Type of examination in special cases |
|
| Examination and assessment criteria |
The portfolio consists of a set of recorded spectra of an unknown compound and a written report of the data for each, organised into tables, and including a detailed analysis and assignment of the signals. The portfolio concludes with a solution to the identity of the unknown compound, including its structure and a discussion of functional groups and sub-structures derived from the analysis of the data. Oral examination: the student will start with a summary of the findings of the portfolio followed by questions by the examiners. Assesment criteria: It will be assessed to which degree the student
Oral examination: all the above and:
Whether the performance meets all formal requirements in regards to both written and oral exam |
| Exam code(s) | |
| Last changed | 05/04/2024 |
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