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Advanced Eukaryotic Cell Biology 1 – Inside the Cell

Title
Advanced Eukaryotic Cell Biology 1 – Inside the Cell
Semester
F2024
Master programme in
Molecular Biology * / Mathematical Bioscience * / Chemical Biology / Mathematical Bioscience / Molecular Health Science
Type of activity

Course

Teaching language
English
Study regulation

Read about the Master Programme and find the Study Regulations at ruc.dk

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REGISTRATION AND STUDY ADMINISTRATIVE
Registration

Sign up for study activities at stads selvbetjening within the announced registration period, as you can see on the Studyadministration homepage.

When signing up for study activities, please be aware of potential conflicts between study activities or exam dates.

The planning of activities at Roskilde University is based on the recommended study programs which do not overlap. However, if you choose optional courses and/or study plans that goes beyond the recommended study programs, an overlap of lectures or exam dates may occur depending on which courses you choose.

Number of participants
ECTS
5
Responsible for the activity
Pia Nyeng (pnyeng@ruc.dk)
Head of study
Lotte Jelsbak (ljelsbak@ruc.dk)
Teachers
Study administration
INM Registration & Exams (inm-exams@ruc.dk)
Exam code(s)
U60179
ACADEMIC CONTENT
Overall objective

Theoretical course in eukaryotic cell biology aiming to give the students a broad knowledge and understanding of form and function of cellular compartments and organelles as well as intracellular regulatory mechanisms

Detailed description of content

Content:

We will discuss essential components and processes INSIDE the cell. The aim is to provide an overview of how the inner mechanisms of the cell support each other. We will follow a flow according to the central dogma: 1) Processes and components in the nucleus (DNA/mRNA) 2) Processes and components in the endomembrane system 3) How are the cellular processes coordinated and organized? (Signaling/Cytoskeleton).

In problem-solving workshops we will practice how to interpret research data and form hypotheses within cell biology, enabling students to develop ideas for master thesis projects in cell & molecular biology.

Topics include:

Molecular structure of chromosomes, Control of gene expression, Membrane structure and transport, Biosynthesis and organelle sorting, Intracellular vesicular trafficking, Cytoskeleton, and Cell signaling.

Course material and Reading list

All course literature is in English. Textbook: ”Molecular Biology of the Cell”, Alberts et al. 6.ed., Garland Science 2015. ISBN 9780815344643.

The curriculum also includes research papers, reviews, and movies, which will be mentioned in the course schedule on Moodle.

Overall plan and expected work effort

Study intensity:

  • Exam 3 hrs

  • Lectures 26 hrs

  • Problem solving and theoretical exercises 6 hrs

  • Question time 2 hrs

  • Preparation 98 hrs

- Total 135 hrs

Teaching and learning activities

  • Lectures, Interactive quizzes, Problem solution in groups
Format
Evaluation and feedback

The course includes formative evaluation based on dialogue between the students and the teacher(s).

Students are expected to provide constructive critique, feedback and viewpoints during the course if it is needed for the course to have better quality. Every other year at the end of the course, there will also be an evaluation through a questionnaire in SurveyXact. The Study Board will handle all evaluations along with any comments from the course responsible teacher.

Furthermore, students can, in accordance with RUCs ‘feel free to state your views’ strategy through their representatives at the study board, send evaluations, comments or insights form the course to the study board during or after the course.

Programme

The course includes a program with the following topics within eukaryotic cell biology. Each topic will be treated during lectures with active participation elements and concluded with a problem solving session.

1) Genetic organization, regulation and expression

2) Cellular membranes, compartments and vesicular trafficking

3) Cellular organization and signaling

A more detailed program is provided in Moodle

ASSESSMENT
Overall learning outcomes

After completing the course, the students will be able to:

  • explain the organization and function of chromosomes, membranes, organelles and cytoskeleton in the eukaryotic cell

  • explain the organization, coordination, and regulation of processes in eukaryotic cells, including gene expression, intracellular protein sorting, vesicular traffic and cell signaling

  • discuss how experiments have contributed to the current principles of cell biology

  • compare the various functions of proteins in eukaryotic cells such as receptors, transport proteins, ion channels and cytoskeletal proteins

  • describe, analyze, and evaluate results from cell biology experiments

  • complete a theoretical review of the latest scientific literature in eukaryotic cell biology

  • formulate new scientific hypotheses as the starting point for a thesis project in eukaryotic cell biology.

Form of examination
Individual written invigilated exam

The duration of the exam is 3 hours.

Permitted support and preparation materials for the exam: Own notes (maximum 10 A4 size pages). Dictionaries and non-programmable pocket calculator.


Assessment: 7-point grading scale
Form of Re-examination
Samme som ordinær eksamen / same form as ordinary exam
Type of examination in special cases
Examination and assessment criteria

Individual written invigilated exam consisting of a main question of 50 points and 5 minor sub-questions of 10 points each. Questions are essay-style and will include data interpretation.

Evaluation criteria: It will be assessed to which degree the student:

  • Explains and describes the organization and function of chromosomes, membranes, organelles and cytoskeleton in the eukaryotic cell

  • Explains and describes the organization, coordination, and regulation of processes in eukaryotic cells, including gene expression, intracellular protein sorting, vesicular traffic and cell signaling

  • Compares and describes the various functions of proteins in eukaryotic cells such as receptors, transport proteins, ion channels and cytoskeletal proteins

  • Describes, analyzes, and evaluates given results/data from cell biological experiments and uses own conclusions to formulate scientific hypotheses

  • Uses appropriate scientific language and terms in English

  • Fulfills all formal exam requirements as described on the front page of the exam set

Exam code(s)
Exam code(s) : U60179
Last changed 07/03/2023

lecture list:

Show lessons for Subclass: 1 Find calendar (1) PDF for print (1)

Monday 05-02-2024 08:15 - 05-02-2024 10:00 in week 06
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 09-02-2024 08:15 - 09-02-2024 10:00 in week 06
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 12-02-2024 08:15 - 12-02-2024 12:00 in week 07
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Thursday 15-02-2024 08:15 - 15-02-2024 10:00 in week 07
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 19-02-2024 10:15 - 19-02-2024 12:00 in week 08
Advanced Eukaryotic Cell Biology 1 (MHS, CB) - Note: Building 07

Thursday 22-02-2024 14:15 - 22-02-2024 16:00 in week 08
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Tuesday 27-02-2024 12:15 - 27-02-2024 14:00 in week 09
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 01-03-2024 08:15 - 01-03-2024 10:00 in week 09
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Thursday 07-03-2024 08:15 - 07-03-2024 10:00 in week 10
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 08-03-2024 08:15 - 08-03-2024 10:00 in week 10
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Tuesday 12-03-2024 10:15 - 12-03-2024 12:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Thursday 14-03-2024 08:15 - 14-03-2024 10:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 15-03-2024 08:15 - 15-03-2024 10:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 18-03-2024 08:15 - 18-03-2024 10:00 in week 12
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Thursday 21-03-2024 08:15 - 21-03-2024 10:00 in week 12
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 25-03-2024 08:15 - 25-03-2024 10:00 in week 13
Advanced Eukaryotic Cell Biology 1 - Question Hour (MHS, CB)

Wednesday 27-03-2024 10:00 - 27-03-2024 13:00 in week 13
Advanced Eukaryotic Cell Biology 1 - Exam (MHS, CB)

Thursday 15-08-2024 10:00 - 15-08-2024 13:00 in week 33
Advanced Eukaryotic Cell Biology 1 - Reexam (MHS, CB)