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Advanced Eukaryotic Cell Biology 1 – Inside the Cell

Title
Advanced Eukaryotic Cell Biology 1 – Inside the Cell
Semester
F2023
Master programme in
Molecular Biology * / Mathematical Bioscience * / Chemical Biology / Mathematical Bioscience / Molecular Health Science
Type of activity

Course

Teaching language
English
Study regulation

Read about the Master Programme and find the Study Regulations at ruc.dk

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REGISTRATION AND STUDY ADMINISTRATIVE
Registration

Sign up for study activities at stads selvbetjening within the announced registration period, as you can see on the Studyadministration homepage.

When signing up for study activities, please be aware of potential conflicts between study activities or exam dates.

The planning of activities at Roskilde University is based on the recommended study programs which do not overlap. However, if you choose optional courses and/or study plans that goes beyond the recommended study programs, an overlap of lectures or exam dates may occur depending on which courses you choose.

Number of participants
ECTS
5
Responsible for the activity
Pia Nyeng (pnyeng@ruc.dk)
Head of study
Lotte Jelsbak (ljelsbak@ruc.dk)
Teachers
Study administration
INM Studieadministration (inm-studieadministration@ruc.dk)
Exam code(s)
U60179
ACADEMIC CONTENT
Overall objective

Theoretical course in eukaryotic cell biology aiming to give the students a broad knowledge and understanding of form and function of cellular compartments and organelles as well as intracellular regulatory mechanisms

Detailed description of content

Content:

We will discuss essential components and processes INSIDE the cell. The aim is to provide an overview of how the inner mechanisms of the cell support each other. We will follow a flow according to the central dogma: 1) Processes and components in the nucleus (DNA/mRNA) 2) Processes and components in the endomembrane system 3) How are the cellular processes coordinated and organized? (Signaling/Cytoskeleton).

In problem-solving workshops we will practice how to interpret research data and form hypotheses within cell biology, enabling students to develop ideas for master thesis projects in cell & molecular biology.

Topics include:

Molecular structure of chromosomes, Control of gene expression, Membrane structure and transport, Biosynthesis and organelle sorting, Intracellular vesicular trafficking, Cytoskeleton, and Cell signaling.

Course material and Reading list

All course literature is in English. Textbook: ”Molecular Biology of the Cell”, Alberts et al. 6.ed., Garland Science 2015. ISBN 9780815344643.

The curriculum also includes research papers, reviews, and movies, which will be mentioned in the course schedule on Moodle.

Overall plan and expected work effort

Study intensity:

  • Exam 3 hrs

  • Lectures 26 hrs

  • Problem solving and theoretical exercises 6 hrs

  • Question time 2 hrs

  • Preparation 98 hrs

- Total 135 hrs

Teaching and learning activities

  • Lectures, Interactive quizzes, Problem solution in groups
Format
Evaluation and feedback

The course includes formative evaluation based on dialogue between the students and the teacher(s).

Students are expected to provide constructive critique, feedback and viewpoints during the course if it is needed for the course to have better quality. Every other year at the end of the course, there will also be an evaluation through a questionnaire in SurveyXact. The Study Board will handle all evaluations along with any comments from the course responsible teacher.

Furthermore, students can, in accordance with RUCs ‘feel free to state your views’ strategy through their representatives at the study board, send evaluations, comments or insights form the course to the study board during or after the course.

Programme

The course includes a program with the following topics within eukaryotic cell biology. Each topic will be treated during lectures with active participation elements and concluded with a problem solving session.

1) Genetic organization, regulation and expression

2) Cellular membranes, compartments and vesicular trafficking

3) Cellular organization and signaling

A more detailed program is provided in Moodle

ASSESSMENT
Overall learning outcomes

After completing the course, the students will be able to:

  • explain the organization and function of chromosomes, membranes, organelles and cytoskeleton in the eukaryotic cell

  • explain the organization, coordination, and regulation of processes in eukaryotic cells, including gene expression, intracellular protein sorting, vesicular traffic and cell signaling

  • discuss how experiments have contributed to the current principles of cell biology

  • compare the various functions of proteins in eukaryotic cells such as receptors, transport proteins, ion channels and cytoskeletal proteins

  • describe, analyze, and evaluate results from cell biology experiments

  • complete a theoretical review of the latest scientific literature in eukaryotic cell biology

  • formulate new scientific hypotheses as the starting point for a thesis project in eukaryotic cell biology.

Form of examination
Individual written invigilated exam.

The duration of the exam is 3 hours.

Permitted support and preparation materials for the exam: Dictionaries and pocket calculator.


Assessment: 7-point grading scale.
Moderation: Internal co-assessor.
Form of Re-examination
Samme som ordinær eksamen
Type of examination in special cases
Examination and assessment criteria

Individual written invigilated exam consisting of a main question of 50 points and 5 minor sub-questions of 10 points each. Questions are essay-style and will include data interpretation.

Evaluation criteria: It will be assessed to which degree the student:

  • Explains and describes the organization and function of chromosomes, membranes, organelles and cytoskeleton in the eukaryotic cell

  • Explains and describes the organization, coordination, and regulation of processes in eukaryotic cells, including gene expression, intracellular protein sorting, vesicular traffic and cell signaling

  • Compares and describes the various functions of proteins in eukaryotic cells such as receptors, transport proteins, ion channels and cytoskeletal proteins

  • Describes, analyzes, and evaluates given results/data from cell biological experiments and uses own conclusions to formulate scientific hypotheses

  • Uses appropriate scientific language and terms in English

  • Fulfills all formal exam requirements as described on the front page of the exam set

Exam code(s)
Exam code(s) : U60179
Last changed 19/09/2022

lecture list:

Show lessons for Subclass: 1 Find calendar (1) PDF for print (1)

Monday 06-02-2023 08:15 - 06-02-2023 10:00 in week 06
Advanced Eukaryotic Cell Biology 1 (MHS, CB) - please note bulding 15

Friday 10-02-2023 08:15 - 10-02-2023 10:00 in week 06
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 13-02-2023 08:15 - 13-02-2023 12:00 in week 07
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 17-02-2023 08:15 - 17-02-2023 10:00 in week 07
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 20-02-2023 08:15 - 20-02-2023 10:00 in week 08
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 24-02-2023 08:15 - 24-02-2023 10:00 in week 08
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 27-02-2023 08:15 - 27-02-2023 10:00 in week 09
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 03-03-2023 08:15 - 03-03-2023 10:00 in week 09
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 10-03-2023 08:15 - 10-03-2023 10:00 in week 10
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 13-03-2023 08:15 - 13-03-2023 10:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Tuesday 14-03-2023 08:15 - 14-03-2023 12:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB) - please note building 15

Friday 17-03-2023 08:15 - 17-03-2023 10:00 in week 11
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 20-03-2023 08:15 - 20-03-2023 10:00 in week 12
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Friday 24-03-2023 08:15 - 24-03-2023 10:00 in week 12
Advanced Eukaryotic Cell Biology 1 (MHS, CB)

Monday 27-03-2023 12:15 - 27-03-2023 14:00 in week 13
Advanced Eukaryotic Cell Biology 1 - Question Hour (MHS, CB)

Friday 31-03-2023 08:30 - 31-03-2023 11:30 in week 13
Advanced Eukaryotic Cell Biology 1 - Exam (MHS, CB)

Monday 07-08-2023 10:00 - 07-08-2023 13:00 in week 32
Advanced Eukaryotic Cell Biology 1 - Reexam (MHS, CB)