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Advanced Eukaryotic Cell Biology 2 - Cellular Mechanisms in Development and Cancer

Title
Advanced Eukaryotic Cell Biology 2 - Cellular Mechanisms in Development and Cancer
Semester
F2023
Master programme in
Molecular Biology * / Mathematical Bioscience * / Chemical Biology / Molecular Health Science
Type of activity

Course

Teaching language
English
Study regulation

Read about the Master Programme and find the Study Regulations at ruc.dk

Læs mere om uddannelsen og find din studieordning på ruc.dk

REGISTRATION AND STUDY ADMINISTRATIVE
Registration

Sign up for study activities at stads selvbetjening within the announced registration period, as you can see on the Studyadministration homepage.

When signing up for study activities, please be aware of potential conflicts between study activities or exam dates.

The planning of activities at Roskilde University is based on the recommended study programs which do not overlap. However, if you choose optional courses and/or study plans that goes beyond the recommended study programs, an overlap of lectures or exam dates may occur depending on which courses you choose.

Number of participants

The Master Programme/Institute reserves the right to cancel the course if fewer than 8 studentes are registered for the course.

ECTS
5
Responsible for the activity
Pia Nyeng (pnyeng@ruc.dk)
Head of study
Lotte Jelsbak (ljelsbak@ruc.dk)
Teachers
Study administration
INM Registration & Exams (inm-exams@ruc.dk)
Exam code(s)
U60186
ACADEMIC CONTENT
Overall objective

Theoretical course in advanced eukaryotic cell biology aiming to give the students an introduction to the regulation of intercellular interactions, with an emphasis on embryonic development, stem cells and cancer.

Detailed description of content

Content:

We will discuss eukaryotic cells in their social context. The aim is to provide an overview of how eukaryotic cells interact with each other and the immediate environment to form and maintain tissues, organs and organisms. We will also discuss how these processes are dysregulated in disease (mostly cancer). The course is mostly focused on mammalian cellular biology.

In problem-solving workshops we will practice how to interpret research data, form hypotheses, and design experiments within cell and tissue biology, enabling students to develop ideas for master thesis projects in cell & molecular biology.

Topics include: Methods and models in cell biology, Cell adhesion and the extracellular matrix, Cell cycle regulation, Cell growth, Programmed cell death, Cancer, Mitochondrial function and genetics, Tissue cell biology, Embryonic development, and Stem cells and cell replacement therapy

Course material and Reading list

All course literature is in English. ”Molecular Biology of the Cell”, Alberts et al. 6.ed., Garland Science 2015. ISBN 9780815344643.

The curriculum also includes research papers, reviews and movies, which will be mentioned in the course schedule on Moodle.

Overall plan and expected work effort

Study intensity:

  • Exam 3 hrs

  • Lectures 26 hrs

  • Problem solving and theoretical exercises 6 hrs

  • Question time 2 hrs

  • Preparation 98 hrs

- Total 135 hrs

Teaching and learning activities

  • Lectures, Interactive quizzes, Problem solution in groups
Format
Evaluation and feedback

The course includes formative evaluation based on dialogue between the students and the teacher(s).

Students are expected to provide constructive critique, feedback and viewpoints during the course if it is needed for the course to have better quality. Every other year at the end of the course, there will also be an evaluation through a questionnaire in SurveyXact. The Study Board will handle all evaluations along with any comments from the course responsible teacher.

Furthermore, students can, in accordance with RUCs ‘feel free to state your views’ strategy through their representatives at the study board, send evaluations, comments or insights form the course to the study board during or after the course.

Programme

The course includes a program with the following main topics within eukaryotic cell biology. Each topic will be treated during lectures with active participation elements and most topics are concluded with a problem solving session.

1) Methods and models in advanced cell biology

2) Mitochondrial function and genetics

3) Cell adhesion and extracellular matrix

4) Regulation of cell number and size

5) Embryonic development and maintenance of tissues and organs

A more detailed program is provided in Moodle

ASSESSMENT
Overall learning outcomes

After completing the course, the students will be able to:

  • explain the organization and function of mitochondria, cellular junctions, extracellular matrix, and tissues of eukaryotic organisms

  • explain the function and regulation of processes in and between eukaryotic cells including adhesion, signaling, cell cycle, differentiation, growth and apoptosis

  • describe and discuss the organization, function and regulation of multi-cellular systems, including embryo development, and homeostasis/cancer in adult tissues

  • discuss how experiments have contributed to the current principles of multicellular biology

  • compare the structure and function of proteins and molecules in eukaryotic cells, such as adhesion proteins, extracellular matrix proteins, receptors and signaling molecules

  • describe, analyze and evaluate results from cell biology experiments

  • design new experiments addressing eukaryotic cell biology questions

  • complete a theoretical review of the latest scientific literature in advanced eukaryotic cell biology, with an emphasis on development and cancer

  • formulate new scientific hypotheses as the starting point for a thesis project in eukaryotic cell biology

Form of examination
Individual written invigilated exam.

The duration of the exam is 3 hours.

Permitted support and preparation materials for the exam: Dictionaries and non-programmable pocket calculator.


Assessment: 7-point grading scale.
Moderation: Internal co-assessor.
Form of Re-examination
Samme som ordinær eksamen / same form as ordinary exam
Type of examination in special cases
Examination and assessment criteria

Individual written invigilated exam consisting of a main question of 50 points and 5 minor sub-questions of 10 points each. Questions are essay-style and will include data interpretation.

Evaluation criteria: It will be assessed to which degree the student:

  • Describes and explains the organization and function of mitochondria, cellular junctions, extracellular matrix and tissues of eukaryotic organisms

  • Describes and explains the function and regulation of processes in and between eukaryotic cells including adhesion, signaling, cell cycle, differentiation, growth and apoptosis

  • Describes and discusses the organization, function and regulation of multi-cellular systems, including embryo development, and homeostasis/cancer in adult tissues

  • Describes and compares the structure and function of proteins and molecules in eukaryotic cells, such as adhesion proteins, extracellular matrix proteins, receptors and signaling molecules

  • Proposes experimental designs and methods to address specified eukaryotic cell biology questions

  • Describes, analyzes, and evaluates given results/data from cell biological experiments and uses own conclusions to formulate scientific hypotheses

  • Uses appropriate scientific language and terms in English

  • Fulfills all formal exam requirements as described on the front page of the exam set

Exam code(s)
Exam code(s) : U60186
Last changed 06/03/2023

lecture list:

Show lessons for Subclass: 1 Find calendar (1) PDF for print (1)

Tuesday 04-04-2023 10:15 - 04-04-2023 12:00 in week 14
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 11-04-2023 10:15 - 11-04-2023 12:00 in week 15
Advanced Eukaryotic Cell Biology 2 (MHS)

Thursday 13-04-2023 14:15 - 13-04-2023 16:00 in week 15
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 18-04-2023 08:15 - 18-04-2023 12:00 in week 16
Advanced Eukaryotic Cell Biology 2 (MHS)

Thursday 20-04-2023 14:15 - 20-04-2023 16:00 in week 16
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 25-04-2023 10:15 - 25-04-2023 12:00 in week 17
Advanced Eukaryotic Cell Biology 2 (MHS)

Thursday 27-04-2023 14:15 - 27-04-2023 16:00 in week 17
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 02-05-2023 12:15 - 02-05-2023 16:00 in week 18
Advanced Eukaryotic Cell Biology 2 (MHS)

Thursday 04-05-2023 14:15 - 04-05-2023 16:00 in week 18
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 09-05-2023 12:15 - 09-05-2023 14:00 in week 19
Advanced Eukaryotic Cell Biology 2 (MHS)

Thursday 11-05-2023 14:15 - 11-05-2023 16:00 in week 19
Advanced Eukaryotic Cell Biology 2 (MHS)

Tuesday 16-05-2023 12:15 - 16-05-2023 14:00 in week 20
Advanced Eukaryotic Cell Biology 2 (MHS)

Friday 19-05-2023 12:15 - 19-05-2023 16:00 in week 20
Advanced Eukaryotic Cell Biology 2 (MHS)

Wednesday 31-05-2023 10:15 - 31-05-2023 12:00 in week 22
Advanced Eukaryotic Cell Biology 2 - Question Hour (MHS)

Friday 02-06-2023 10:00 - 02-06-2023 13:00 in week 22
Advanced Eukaryotic Cell Biology 2 - Exam (MHS)

Friday 11-08-2023 10:00 - 11-08-2023 13:00 in week 32
Advanced Eukaryotic Cell Biology 2 - Reexam (MHS)