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Genomics and Metabolism (Elective course in MHS / Seminarkursus i Medicinalbiologi)

Title
Genomics and Metabolism (Elective course in MHS / Seminarkursus i Medicinalbiologi)
Semester
E2022
Master programme in
Medical biology * / Chemical Biology / Mathematical Bioscience / Molecular Health Science
Type of activity

Course

Teaching language
English
Study regulation

Read about the Master Programme and find the Study Regulations at ruc.dk

Læs mere om uddannelsen og find din studieordning på ruc.dk

REGISTRATION AND STUDY ADMINISTRATIVE
Registration

Sign up for study activities at stads selvbetjeningwithin the announced registration period, as you can see on the Studyadministration homepage.

When signing up for study activities, please be aware of potential conflicts between study activities or exam dates.

The planning of activities at Roskilde University is based on the recommended study programs which do not overlap. However, if you choose optional courses and/or study plans that goes beyond the recommended study programs, an overlap of lectures or exam dates may occur depending on which courses you choose.

Number of participants

The Master Programme/Institute reserves the right to cancel the course if fewer than 8 studentes are registered for the course.

ECTS
5
Responsible for the activity
Jesper Troelsen (troelsen@ruc.dk)
Head of study
Lotte Jelsbak (ljelsbak@ruc.dk)
Teachers
Study administration
INM Studieadministration (inm-studieadministration@ruc.dk)
Exam code(s)
U60174
ACADEMIC CONTENT
Overall objective

The course covers molecular, biochemical, medical, physiological and cellular biological responses, mechanisms and adaptations in humane intestine. The main emphasis is on knowledge and understanding, theory and scientific methods and oral presentation. The content of the individual courses appears in the course description on study.ruc.dk.

Detailed description of content

The course consists of a mixture of lectures, presentation of presentations from students, discussion, and can include group work and peer feedback.

It is organized around a number of themes within intermediate metabolism and genomic methods.

Diabetes epidemiology and genetics, beta cell, its embryonic development and stem cells, mechanisms of beta cell killing in type 1 diabetes, development of insulin resistance, low-grade inflammation and beta cell failure in type 2 diabetes.

Research techniques and animal models within intermediate metabolism and diseases of the intestinal system with special focus on, genomics techniques such as: Genome sequencing, SNP analyzes, miRNA sequencing, mRNA profiling by Array and RNAseq analyzes, CAGE analyzes chromatin immunoprecipitation (ChIP-seq), and epigenetic chromat markers.

Passing the course is based on regular and active participation. Regular and active participation means that there is a requirement for attendance in 80% of the teaching, as well as active participation in the teaching (be prepared, participate in discussions, make presentations, etc.). Attendance is registered by name lists and the teacher assesses whether the participation is active.

Course material and Reading list

Research articles for each teaching session.

Overall plan and expected work effort
  • Lectures 4 hours

  • Colloquia 28 hours

  • Preparation 103 hours

  • A total of 135 hours

Format
Evaluation and feedback

The course includes formative evaluation based on dialogue between the students and the teacher(s).

Students are expected to provide constructive critique, feedback and viewpoints during the course if it is needed for the course to have better quality. Every other year at the end of the course, there will also be an evaluation through a questionnaire in SurveyXact. The Study Board will handle all evaluations along with any comments from the course responsible teacher.

Furthermore, students can, in accordance with RUCs ‘feel free to state your views’ strategy through their representatives at the study board, send evaluations, comments or insights form the course to the study board during or after the course.

Programme
  • Introduction.

Genomics:

  • Transcriptome

  • microRNAome

  • Genome

  • Regulatome

  • Microbiome

  • Cell free DNA

Metabolism

  • Diabetes epidermology

  • Metabolisc syndrome

  • Obesity and Prediabetes

  • Microbiome and diabetes

  • Beta cells

  • Diabetes genetics and management

ASSESSMENT
Overall learning outcomes

After completing the course, the students will be able to:

  • describe central physiological processes in human intestines

  • discuss the different physiological and regulatory responses in human intestines to changes in the internal or external environment

  • gather relevant knowledge and understanding from scientific review articles, and critically analyse new and original scientific literature, interpret and evaluate experimental data and hypotheses in molecular biology, health science, physiology or cellular biology

  • make oral presentations of scientific hypotheses, results and interpretations to fellow students

  • reflect upon the latest scientific hypotheses and experiments in the course’s subject area

  • rormulate a relevant research question and a testable hypothesis as a basis for an experimental thesis project related to health science, biochemistry, physiology or cellular biology.

Form of examination
The course is passed through active, regular attendance and satisfactory participation.

Active participation is defined as:
The student must participate in course related activities (e.g. workshops, seminars, field excursions, process study groups, working conferences, supervision groups, feedback sessions).

Regular attendance is defined as:
- The student must be present for minimum 80 percent of the lessons.

Satisfactory participation is defined as:
- e.g. oral presentations (individually or in a group), peer reviews, mini projects, test, planning of a course session .

Assessment: Pass/Fail.
Form of Re-examination
Individual written take-home assignment

The character limit of the assignment is: 12,000-28,800 characters, including spaces.
The character limit includes the cover, table of contents, bibliography, figures and other illustrations, but exclude any appendices.

The duration of the take-home assignment is 7 days and may include weekends and public holidays.



Assessment: Pass/Fail.
Type of examination in special cases
Examination and assessment criteria

Active participation is defined as: the above and more specific the students are expected to take active part in the discussions following the presentations.

Satisfactory participation is defined as: one presentation in genomics and one presentation in metabolomics.

Assessment criteria: - make oral presentations of scientific hypotheses, results and interpretations to fellow students

  • reflect upon the latest scientific hypotheses and experiments in the course’s subject area
Exam code(s)
Exam code(s) : U60174
Last changed 24/06/2022

lecture list:

Show lessons for Subclass: 1 Find calendar (1) PDF for print (1)

Thursday 08-09-2022 12:15 - 08-09-2022 14:00 in week 36
Genomics and Metabolism (MHS)

Thursday 15-09-2022 12:15 - 15-09-2022 14:00 in week 37
Genomics and Metabolism (MHS)

Thursday 22-09-2022 12:15 - 22-09-2022 14:00 in week 38
Genomics and Metabolism (MHS)

Thursday 29-09-2022 12:15 - 29-09-2022 14:00 in week 39
Genomics and Metabolism (MHS)

Friday 07-10-2022 09:15 - 07-10-2022 11:00 in week 40
Genomics and Metabolism (MHS)

Thursday 13-10-2022 12:15 - 13-10-2022 14:00 in week 41
Genomics and Metabolism (MHS)

Thursday 20-10-2022 12:15 - 20-10-2022 14:00 in week 42
Genomics and Metabolism (MHS)

Thursday 27-10-2022 12:15 - 27-10-2022 14:00 in week 43
Genomics and Metabolism (MHS)

Thursday 03-11-2022 12:15 - 03-11-2022 14:00 in week 44
Genomics and Metabolism (MHS)

Thursday 10-11-2022 12:15 - 10-11-2022 14:00 in week 45
Genomics and Metabolism (MHS)

Thursday 17-11-2022 12:15 - 17-11-2022 14:00 in week 46
Genomics and Metabolism (MHS)

Thursday 24-11-2022 12:15 - 24-11-2022 14:00 in week 47
Genomics and Metabolism (MHS)

Thursday 01-12-2022 12:15 - 01-12-2022 14:00 in week 48
Genomics and Metabolism (MHS)

Thursday 08-12-2022 12:15 - 08-12-2022 14:00 in week 49
Genomics and Metabolism (MHS)

Thursday 15-12-2022 12:15 - 15-12-2022 14:00 in week 50
Genomics and Metabolism (MHS)

Friday 17-02-2023 10:00 - Friday 24-02-2023 10:00 in week 07 and week 08
Genomics and Metabolism - Take-home assigment (reexam) (MHS)